ea0029p1 | Adrenal cortex | ICEECE2012
Ragazzon B.
, Gaujoux S.
, Hantel C.
, Tissier F.
, Rizk-Rabin M.
, Beuschlein F.
, Bertherat J.
Adrenocortical carcinoma (ACC) is a rare and highly aggressive endocrine neoplasm, with limited therapeutic option. Activating β-catenin somatic mutations are observed in ACC and associated with a poor outcome. Activation of the Wnt/β-catenin signaling pathway seems to play a major role in ACC aggressiveness, and might be a promising therapeutic target. The H295 cell line derived from an ACC harbors an activating β-catenin mutation. We herein assess the in vi...